TYK2
Tyrosine kinase 2 (TYK2) mediates the signals triggered by certain cytokines.1
- IL-12-induced TYK2 activation initiates recruitment and phosphorylation of STAT4 which activates transcription of a major effector molecule in systemic immune disorders.1,2
- IL-23 signaling through TYK2 is critical in the expansion and survival of pathogenic TH17 cells as well as the induction of innate lymphoid cells in autoimmunity.1-3
- Activation by type I IFNs signaling through TYK2 in the B cell impacts pathways important in autoimmunity such as B cell differentiation, antibody production, and immunoglobulin isotype class switching.4
TYK2 mediates immune and inflammatory signaling pathways critical in the pathophysiology of
immune-mediated diseases5-12
TYK2 Mechanism of Pathway Video
References
- Ishizaki M, Akimoto T, Muromoto R, et al. J Immunol. 2011;187:181-189.
- Paunovic V, Carroll HP, Vandenbroeck K, et al. Rheumatology. 2008;47:771-776.
- Geremia AG, Arancibia-Carcamo CV, Fleming MPP, et al. J Exp Med. 2011;208(6):1127-1133.
- Ronnblom L, Eloranta M-L, Alm GV. Arthritis Rheum. 2006;54(2):408-420.
- Min X et al. J Biol Chem . 2015;290:27261-27270.
- Gillooly K et al. Poster presentation at ACR/ARHP 2016. Abstract 11L.
- Miao W et al. Poster presentation at ACR/ARHP 2016. Abstract 1911.
- Jani M et al. Ann Rheum Dis. 2014;73:1750-1752.
- Smith JA, Colbert RA. Arthritis Rheumatol. 2014;66:231-241.
- Hofer MJ, Campbell IL. Cytokine Growth Factor Rev. 2013;24:257-267.
- Paniagua RT et al. J Am Acad Dermatol. 2011;65:389-403.
- O'Sullivan LA et al. Mol Immunol. 2007;44:2497-2506.
- Ghoreschi K et al. Immunol Rev. 2009;228:273-287.
- Tokarski JS et al. J Biol Chem. 2015;290:11061-11074.
- Simmons DP et al. J Immunol. 2012;188:3116-3126.
- Eloranta M-L, Rönnblom L. J Mol Med. 2016;94:1103-1110.
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