TYK2

Tyrosine kinase 2 (TYK2) mediates the signals triggered by certain cytokines.1

  • IL-12-induced TYK2 activation initiates recruitment and phosphorylation of STAT4 which activates transcription of a major effector molecule in systemic immune disorders.1,2
  • IL-23 signaling through TYK2 is critical in the expansion and survival of pathogenic TH17 cells as well as the induction of innate lymphoid cells in autoimmunity.1-3
  • Activation by type I IFNs signaling through TYK2 in the B cell impacts pathways important in autoimmunity such as B cell differentiation, antibody production, and immunoglobulin isotype class switching.4

TYK2 mediates immune and inflammatory signaling pathways critical in the pathophysiology of
immune-mediated diseases5-12

TYK2 Mechanism of Pathway Video

View areas of research related to TYK2

References

  1. Ishizaki M, Akimoto T, Muromoto R, et al. J Immunol. 2011;187:181-189.
  2. Paunovic V, Carroll HP, Vandenbroeck K, et al. Rheumatology. 2008;47:771-776.
  3. Geremia AG, Arancibia-Carcamo CV, Fleming MPP, et al. J Exp Med. 2011;208(6):1127-1133.
  4. Ronnblom L, Eloranta M-L, Alm GV. Arthritis Rheum. 2006;54(2):408-420.
  5. Min X et al. J Biol Chem . 2015;290:27261-27270.
  6. Gillooly K et al. Poster presentation at ACR/ARHP 2016. Abstract 11L.
  7. Miao W et al. Poster presentation at ACR/ARHP 2016. Abstract 1911.
  8. Jani M et al. Ann Rheum Dis. 2014;73:1750-1752.
  9. Smith JA, Colbert RA. Arthritis Rheumatol. 2014;66:231-241.
  10. Hofer MJ, Campbell IL. Cytokine Growth Factor Rev. 2013;24:257-267.
  11. Paniagua RT et al. J Am Acad Dermatol. 2011;65:389-403.
  12. O'Sullivan LA et al. Mol Immunol. 2007;44:2497-2506.
  13. Ghoreschi K et al. Immunol Rev. 2009;228:273-287.
  14. Tokarski JS et al. J Biol Chem. 2015;290:11061-11074.
  15. Simmons DP et al. J Immunol. 2012;188:3116-3126.
  16. Eloranta M-L, Rönnblom L. J Mol Med. 2016;94:1103-1110.