TLR 7/8

Toll-like receptors (TLR) 7 and 8 play important roles in immune surveillance. However, overactivation of TLR7 and TLR8 by ssRNA released from tissue damage may contribute to the pathogenesis of lupus.1-5

  • TLR7 activation enhances B-cell differentiation,1,2 increasing autoantibody production and immune complex formation.3
  • TLR7 in pDCs stimulates type I IFN and cytokine production, enhancing the immune response.1
  • TLR8 activation in mDCs, as well as TLR7 and TLR8 activation in monocytes and macrophages, stimulates production of proinflammatory cytokines.1,2,4,5
  • Increased NF-кβ activation by TLR7 and TLR8 is associated with steroid resistance.6,7

Toll-Like Receptors 7 and 8 (TLR 7/8)

References

  1. GFillatreau S, et al. Nat Rev Rheumatol. 2021;17(2):98-108.
  2. Rahman AH, Eisenberg RA. Semin Immunol. 2006;28:131-143.
  3. Wallace DJ, et al. Nat Rev Rheumatol. 2012;8(9):522-33.
  4. Dowling DJ. ImmunoHorizons. 2018;2(6):185-197.
  5. Arpaia N, Barton GM. Curr Opin Virol. 2011;1:447-454.
  6. Guiducci C, et al. Nature. 2010;465(7300):937-41.
  7. Luijten RK, et al. Autoimmun Rev. 2013;12(5):617-28.