S1P-1R
- Sphingosine 1-phosphate (S1P) is a sphingolipid signaling molecule that activates five S1P receptors with multiple physiologic functions, including regulation of lymphocyte traffic.1,2
- Lymphocytes expressing S1P1 receptors on their surface can bind to and use the S1P gradient to migrate out of lymphoid tissue and subsequently join the circulation.2
- Bristol Myers Squibb has conducted research within the S1P pathway, with extensive experience in immune mediated diseases, including multiple sclerosis, ulcerative colitis, and atopic dermatitis.
References
- Ziegler AC, Gräler MH. Tissue Barriers. 2021;9(4):1940069.
- Bamias G, Clark DJ, Rivera-Nieves J. Curr Drug Targets. 2013;14(12):1490-1500.
- Thangada S, Khanna KM, Blaho VA, et al. J Exp Med. 2010;207(7):1475-1483.
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