OX40

   
  • OX40 is an activating, transmembrane receptor protein that is expressed on the surface of activated cytotoxic T cells and Tregs.1-3
  • OX40 both activates and amplifies T-cell responses, helping to create a tumor microenvironment more favorable to the antitumor immune response.4-6
  • Preclinical data suggest that OX40 signaling increases the number and activity of cytotoxic T cells and curtails the immunosuppressive impact of Tregs.4-6

Treg=regulatory T cell.

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References

  1. Evans DE et al. J Immunol. 2001;167(12):6804-6811.
  2. Ruby CE et al. Eur J Immunol. 2007;37(1):157-166.
  3. Tittle TV et al. Blood. 1997;89(12):4652-4658.
  4. Piconese S et al. J Exp Med. 2008;205(4):825-839.
  5. Weinberg AD et al. J Immunol. 2000;164(4):2160-2169.
  6. Gough MJ et al. Cancer Res. 2008;68(13):5206-5215.