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    Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2)
    • Immunology
    • BTK
    • CTLA-4
    • IL-13
    • MK2
    • PAD
    • S1P-1R
    • TLR 7/8
    • TYK2

    MK2

    The kinase MK2 mediates proinflammatory cytokine production by regulating mRNA stability.1,2

    • MK2 is a serine threonine intracellular protein kinase, and the prime downstream substrate of p38MAPK, a signaling cascade that can be activated by stress and inflammatory stimuli.1-3
    • Activation of MK2 by p38 enables the stabilization of mRNA resulting in translation and production of pro-inflammatory cytokines such as TNFα and IL-17.1,2,4
    • TNFα and IL-17 have been implicated in the pathogenesis of ankylosing spondylitis (AS).4,5

    Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2)

    References

    1. Gaestel M. Nat Rev Mol Cell Biol. 2006;7:120-130.
    2. Hitti E, et al. Mol Cell Biol.2006;26:2399-2407.
    3. Vittal R, et al. Am J Respir Cell Mol Biol. 2013;49(1):47-57.
    4. Ramirez-Valle F, et al. Arthritis Rheumatol. 2019;71(Suppl 10).
    5. Taurog JD, et al. N Engl J Med. 2016;374(26):2563-2574.
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