MK2

The kinase MK2 mediates proinflammatory cytokine production by regulating mRNA stability.1,2

  • MK2 is a serine threonine intracellular protein kinase, and the prime downstream substrate of p38MAPK, a signaling cascade that can be activated by stress and inflammatory stimuli.1-3
  • Activation of MK2 by p38 enables the stabilization of mRNA resulting in translation and production of pro-inflammatory cytokines such as TNFα and IL-17.1,2,4
  • TNFα and IL-17 have been implicated in the pathogenesis of ankylosing spondylitis (AS).4,5

Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2)

References

  1. Gaestel M. Nat Rev Mol Cell Biol. 2006;7:120-130.
  2. Hitti E, et al. Mol Cell Biol.2006;26:2399-2407.
  3. Vittal R, et al. Am J Respir Cell Mol Biol. 2013;49(1):47-57.
  4. Ramirez-Valle F, et al. Arthritis Rheumatol. 2019;71(Suppl 10).
  5. Taurog JD, et al. N Engl J Med. 2016;374(26):2563-2574.