MK2
The kinase MK2 mediates proinflammatory cytokine production by regulating mRNA stability.1,2
- MK2 is a serine threonine intracellular protein kinase, and the prime downstream substrate of p38MAPK, a signaling cascade that can be activated by stress and inflammatory stimuli.1-3
- Activation of MK2 by p38 enables the stabilization of mRNA resulting in translation and production of pro-inflammatory cytokines such as TNFα and IL-17.1,2,4
- TNFα and IL-17 have been implicated in the pathogenesis of ankylosing spondylitis (AS).4,5
References
- Gaestel M. Nat Rev Mol Cell Biol. 2006;7:120-130.
- Hitti E, et al. Mol Cell Biol.2006;26:2399-2407.
- Vittal R, et al. Am J Respir Cell Mol Biol. 2013;49(1):47-57.
- Ramirez-Valle F, et al. Arthritis Rheumatol. 2019;71(Suppl 10).
- Taurog JD, et al. N Engl J Med. 2016;374(26):2563-2574.