IL-13

IL-13 is a key cytokine produced by Th2 cells and involved in allergic inflammation.1

  • IL-13 signals through two receptors, IL-13Rα1 and IL-13Rα2, to modulate cellular and molecular pathways involved in functions including eosinophil recruitment, esophageal barrier function, tissue remodeling, and fibrosis.2-4
  • IL-13Rα1 is a subunit of the type II IL-4 receptor, forming an IL-4Ra/IL-13Ra1 complex that binds IL-13, resulting in the activation of the JAK/STAT; JAK2/TYK2 pathway, specifically activation of STAT6, followed by the activation of gene transcription.4
  • IL-13 also binds the cell surface IL-13Rα2, which some believe to be an inhibitory subunit of the type II receptor, though it can also have other roles.5

References

  1. Rochman M et al. JCI Insight. 2017;2(20):e96789.
  2. Doran E et al. Front Med (Lausanne). 2017;4:139.
  3. Zuo L et al. J Immunol. 2010;185(1):660-9.
  4. McCormick SM et al. Cytokine. 2015;75(1):38-50.
  5. Gour N et al. Cytokine. 2015;75(1):68.