FucGM1

     
  • FucGM1 is a ganglioside that has limited expression in normal tissues. While it is mostly expressed in neural tissue, it is also highly expressed on the surface of tumor cells in SCLC.1-3
  • Gangliosides such as FucGM1 are cell surface glycosphingolipids that enable cell-cell recognition, adhesion, and signaling transduction.1
  • Research suggests that antibodies targeting FucGM1 promote complement activation. FucGM1 antibodies may impart synergistic cytotoxic effects with other signaling pathways.1

FucGM1=fucosyl GM1; SCLC=small cell lung cancer.

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References

  1. Ponath P et al. Clin Cancer Res. 2018;24(20):5178-5189.
  2. Daniotti J et al. Front Oncol. 2013;3:306.
  3. Dickler M et al. Clin Cancer Res. 1999;5(10):2773-9.