CTLA-4
T cell activation by antigen-presenting cell (APC) requires co-stimulatory signaling.1
- Binding of the CD28 receptor to ligands CD80 or 86 on an antigen-presenting cell (APC) provides a co-stimulatory signal requisite for T cell activation and the consequent inflammatory cascade.1 This interaction is followed by T cell expression of cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4).2
- In the normal immune response, CTLA-4 competes for CD28 binding to CD80/86. CTLA-4 has a higher binding affinity for CD80/86 and its binding blocks T cell activation by CD28.2
- In addition, CTLA-4 binding delivers a negative signal that downregulates T cell function and inhibits the excessive expansion of activated T cells.2
References
- Suchard SJ, Davis PM, Kansal S, et al. J Immunol. 2013;191:4599-4610.
- Vasaturo A, Di Blasio S, Peeters DGA, et al. Frontiers Immunol. 2013;4:417.
Log In
Log in below to access your account on BMS Science or Bolder Science. If you have an existing Bolder Science account, please use your login credentials for that account here.
Please enter your email address.
You will receive a link to create a new password via email.
Create Account
Use the form below to create one account that will be used across both BMS Science and Bolder Science. Clinical trials that you save on either site will be shown together on your dashboard on Bolder Science. If you already have an account, you can log in here.
