Bruton’s tyrosine kinase (BTK) is a nonreceptor tyrosine kinase and is essential in regulating signaling of multiple pathways implicated in immune-mediated disease.1-4 

  • Following antigen recognition and binding by the surface B cell receptor, BTK is recruited to the cell membrane where it becomes activated by a series of phosphorylations.2
  • B cells, in addition to being a source of autoantibodies, also play a critical role in immune-mediated disease through antibody-independent mechanisms, including the action of B cells as antigen-presenting cells and as sources of pro-inflammatory cytokines.3
  • BTK is also expressed to high levels in myeloid lineages and regulates the signaling pathways leading to expression of pro-inflammatory cytokines, induced through the binding of immune complexes to the Fcγ and Fcε receptors in immune-mediated disease.1
  • BTK mediates RANKL-dependent osteoclastogenesis from monocyte lineage precursors.4 

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  1. Chu AD, Chang BY. OA Arthritis. 2013;1(2):17.
  2. Akinleye A, Chen Y, Mukhi N, Song Y, Liu D. J Hematol Oncol. 2013;6:59.
  3. Burmester GR, Feist E, Dorner T. Nature. 2014;10:77-88.
  4. Lee SH, Kim T, Jeong D, et al. J Biol Chem. 2008;283(17):11526-11534.