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    Bruton’s Tyrosine Kinase (BTK)
    • Immunology
    • BTK
    • CTLA-4
    • IL-13
    • MK2
    • PAD
    • S1P-1R
    • TLR 7/8
    • TYK2

    BTK

    Bruton’s tyrosine kinase (BTK) is a nonreceptor tyrosine kinase and is essential in regulating signaling of multiple pathways implicated in immune-mediated disease.1-4 

    • Following antigen recognition and binding by the surface B cell receptor, BTK is recruited to the cell membrane where it becomes activated by a series of phosphorylations.2
    • B cells, in addition to being a source of autoantibodies, also play a critical role in immune-mediated disease through antibody-independent mechanisms, including the action of B cells as antigen-presenting cells and as sources of pro-inflammatory cytokines.3
    • BTK is also expressed to high levels in myeloid lineages and regulates the signaling pathways leading to expression of pro-inflammatory cytokines, induced through the binding of immune complexes to the Fcγ and Fcε receptors in immune-mediated disease.1
    • BTK mediates RANKL-dependent osteoclastogenesis from monocyte lineage precursors.4 

    References

    1. Chu AD, Chang BY. OA Arthritis. 2013;1(2):17.
    2. Akinleye A, Chen Y, Mukhi N, Song Y, Liu D. J Hematol Oncol. 2013;6:59.
    3. Burmester GR, Feist E, Dorner T. Nature. 2014;10:77-88.
    4. Lee SH, Kim T, Jeong D, et al. J Biol Chem. 2008;283(17):11526-11534.
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