BCMA (CAR T, TCE, ADC)

B-cell maturation antigen (BCMA) is a transmembrane protein member of the tumor necrosis factor (TNF) receptor superfamily, predominantly expressed on plasma cells, including malignant myeloma cells.1-3 Preclinical studies have shown that BCMA is essential for the survival of these cell types.1,3 Therefore, BCMA is a promising target protein in multiple myeloma through investigational therapies such as chimeric antigen receptor (CAR) T cell therapy, bispecific T-cell engagers, and antibody drug conjugates, among others.1,2

BCMA molecular pathway research

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References

  1. Seckinger A, et al. Cancer Cell. 2017;31:396-410. PMID: 28262554
  2. Tai Y, Anderson K. Immunotherapy. 2015;7:1187-1199. PMID: 26370838
  3. O'Connor BP, et al. J Exp Med. 2004;199:91-98. PMID: 14707116